Thanks to @alarixnia fot the patch and bugreport.
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Forwarding a bug reported using the NetBSD bug tracker ("Profanity crashes at login"): http://gnats.netbsd.org/57050
The code in question here handles messages by people not in the user's contact list, and what is probably happening is that the XMPP server is sending such a message before profanity has set up its window layout.
Setting roster.unsubscribed=false indeed makes profanity start without crashing, and the attached patch bails out early in the problematic code path if layout->subwin is NULL (Adrian verified for me that either of the two makes profanity work for him again). But I am not familiar enough with the profanity code to say if this has any issues.
Profanity compiled with ncurses doesn't crash because ncurses's wattron() has a guard against the user passing null pointers, but the X/Open curses library standard doesn't have this guarantee and there's no guard in the NetBSD curses implementation.
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Fix https://github.com/profanity-im/profanity/issues/1769
62e98dee74